Differences between smoking alternatives like vape & e cig vs cigarettes IQOS (heated tobacco) replaces vaping as the next cigarette alternative Bridge Michigan A Randomized Trial of E Cigarettes versus Nicotine Replacement Therapy New England Journal of Medicine The nicotine in 1 vape can equal 50 cigarettes. Depending on the size of the vape and nicotine strength, it can be much higher. Nicotine can harm the developing brain, affecting Vapin is twice as effective as nicotine replacement options Vaped