Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3 Cagrilintide: The Peptide That Makes You Forget About Food. I call it the silence between cravings. Cagrilintide is a long acting amylin analog which means it works alongside leptin and GLP 1 to CagrisSema is a once weekly injection of semaglutide and cagrilintide. Phase 2 clinical trial results for CagriSema showed significant improvements in A1C, weight loss, and time in range, marking it as a promising Cagrilintide Peptide Cagrilintide Medlabs Peptides Cagrilintide is a long acting amylin analog that regulates appetite, gastric emptying, and glucagon secretion to treat obesity and related metabolic disorders. There are 2 pathways cagrilintide works: