Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Frontiers Acetaminophen induced liver injury: Molecular mechanism and treatments from natural products Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: