Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Induced Hepatotoxicity: a Comprehensive Update Acetaminophen C8H9NO2 CID 1983 PubChem Figure 1: CMAJ Acetaminophen detoxification in cucumber plants via induction of glutathione S transferases ScienceDirect
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