Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Acetaminophen Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Tylenol's Impact on Glutathione and Liver Damage How can I minimize liver damage while taking Tylenol (acetaminophen) in relation to glutathione levels?