Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Melanosis coli** Melanosis coli is a benign, reversible condition characterized by brown black pigmentation of the colonic mucosa, most often due to chronic use of anthraquinone laxatives. The discoloration is caused Pathology Outlines Melanotic macule Oral Mucosal Melanosis IntechOpen Melanotic macules of the tongue in a newborn Journal of the American Academy of Dermatology