Melanosis Coli El Atlas Gastrointestinal gastrointestinalatlas.com Melanosis coli followed up with colonoscopy for seven months after ces IMCRJ Dove Medical Press PT 141 Injection Pen Australia Subcutaneous PT 141 Inject+ Leopard skin appearance on colonoscopy. Melanosis coli is a condition characterized by dark brown or black pigmentation of the colon lining, often resulting from the prolonged use of anthraquinone laxatives like senna Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association