What is a MTHFR gene mutation? Methyl Life Supplements What is a MTHFR gene mutation? Methyl Life Supplements The detox gene (MTHFR) is rendered inactive when your diet is high in meat. Our diet should be 80% plant based or higher. Understanding MTHFR genetic variation and its connection to glutathione production Methylenetetrahydrofolate reductase and psychiatric diseases Translational Psychiatry