Advancements in Clinical Research and Development of Obesity Treatment Medications Structural and mechanistic insights into dual activation of cagrilintide in amylin and calcitonin receptors Acta Pharmacologica Sinica Cagrilintide medication for weight loss and appetite control Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3 eBioMedicine Semaglutide and cagrilintide have each been shown to induce weight loss, but how these drugs work in combination in patients with type 2 diabetes and overweight or obesity is unknown. Research findings