Acetaminophen toxicity Most patients who overdose on acetaminophen will initially be asymptomatic, as clinical symptoms of end organ toxicity do not manifest until 24 48 hours after an acute ingestion. Therefore, to identify a 5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. Liposomal Glutathione Sunny Within Acetaminophen toxicity EMCrit Project Liposomal Glutathione Watermelon The Ruscio Institute LLC