GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Why glutathione isn't the antidote Explained though concept chain from Simplify Rx Hepatotoxicity: Mechanisms of Liver Injury Springer Nature Link Ursolic acid alleviates tetrandrine induced hepatotoxicity by competitively binding to the substrate binding site of glutathione S transferases ScienceDirect Predicting hepatotoxicity: Reactive metabolite trapping using glutathione and freshly isolated hepatocytes Technology Networks