Tox and Hound Fellow Friday What Terror Hath NAPQI Wrought? Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite Acute acetaminophen paracetamol toxicity Mechanisms of Hepatocyte Detoxification Abdominal Key Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing)
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napqi and glutathione GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. ❓How does ethanol interfere with acetaminophen metabolism? Image: https://t.co/6EY9dIwLXY