Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Tylenol (acetaminophen) may seem harmless But it could be working against your body's ability to heal. Depletes glutathione, your body's master antioxidant (Prescott, J Clin Invest, 1982) Glutathione is Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine The Metabolism of Acetaminophen and the Synthesis of Glutathione Download Scientific Diagram Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology