Potential Role of Glutathione Antioxidant Pathways in the Pathophysiology and Adjunct Treatment of Psychiatric Disorders Thioredoxin and Glutathione Systems Springer Nature Link Pentose Phosphate Pathway made simple. This pathway has two major jobs: Generate NADPH Produce ribose 5 phosphate NADPH protects cells from oxidative stress and supports fatty acid, cholesterol, steroid, nitric oxide, and respiratory burst Antioxidant Protection of NADPH Depleted Oligodendrocyte Precursor Cells Is Dependent on Supply of Reduced Glutathione Ewa Kilanczyk, Sujata Saraswat Ohri, Scott R. Whittemore, Michal Hetman, 2016 Frontiers Glutathione and mitochondria