Figure 1: CMAJ Paracetamol is one of the most commonly used analgesic and antipyretic drugs. Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Acetaminophen (Paracetamol) Toxicity A common and potentially fatal cause of acute liver failure due to toxic accumulation of the metabolite NAPQI when glutathione stores are depleted. Early recognition and timely administration