Can your vape activate smoke detectors? Vuse Does Vape Trigger Smoke Alarm Will Vaping Trigger a Smoke Detector? (And How to Avoid It) Can a Vape Detector Detect Cigarette and Marijuana Smoke? setting off a smoke detector using a vape Think vapes are harmless to your smoke alarms? Not always. Vapor clouds from ecigarettes can drift into smoke alarms and trigger false alarms, especially in smaller rooms. Even lighter vapes can